If a statistic is bolded this means that the player led their league in that stat. If the statistic is italicized then they led the entire majors in the stat. For example, Francisco Lindor led the American League in Plate Appearances and At Bats in 2017 and so those stats are bolded. In 2018 Lindor led the AL in At Bats (bold) and both the AL and the majors as a whole in Plate Appearances and Runs (bold and italics).
Leading the majors without leading a league
It is possible for a player to lead the majors as a whole in a statistic without leading an individual league in that stat. For example, in 1997 Mark McGwire hit 34 home runs in the American League with the Oakland Athletics, and 24 in the National League with the St. Louis Cardinals. His combined 58 home runs led the entire majors, but he led neither the AL or NL individually: Ken Griffey Jr. was first in the AL with 56 HR (besting McGwire's 34) and Jeff Bagwell led the NL with 49 HR (against McGwire's 24 NL dingers).
In this instance the stat will be italicized without being bolded.